A Shift from Reversible to Irreversible X Inactivation Is Triggered during ES Cell Differentiation
نویسندگان
چکیده
منابع مشابه
From Reversible to Irreversible Computations
In this paper we study the relation between reversible and irreversible computation applicable to different models of computation — here we are considering classical and quantum computation. We develop an equational theory of reversible computations and an associated theory of irreversible computations which is obtained by marking some inputs as preinitialised heap and some outputs as garbage t...
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AIMS Differentiation of cardiac fibroblasts (Fbs) into myofibroblasts (MyoFbs) is responsible for connective tissue build-up in myocardial remodelling. We examined MyoFb differentiation and reversibility. METHODS AND RESULTS Adult rat cardiac Fbs were cultured on a plastic substratum providing mechanical stress, with conditions to obtain different levels of Fb differentiation. Fb spontaneousl...
متن کاملLive-Cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events during ES Cell Differentiation
Random X inactivation represents a paradigm for monoallelic gene regulation during early ES cell differentiation. In mice, the choice of X chromosome to inactivate in XX cells is ensured by monoallelic regulation of Xist RNA via its antisense transcription unit Tsix/Xite. Homologous pairing events have been proposed to underlie asymmetric Tsix expression, but direct evidence has been lacking ow...
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چکیده: هدف اصلی این مطالعه ی توصیفی تحقیقی در حقیقت تلاشی پساروش-گرا به منظور رسیدن به نتیجه ای منطقی در انتخاب مناسبترین راهکار آموزشی بر گرفته از چارچوب راهبردی مطرح شده توسط والدمر مارتن بوده که به بهترین شکل سازگار و مناسب با سامانه ی آموزشی ایران باشد. از این رو، دو راهکار آموزشی، راهکار ارتباطی و راهکار بازساختی، برای تحقیق و بررسی انتخاب شدند. صریحاً اینکه، در راستای هدف اصلی این پژوهش، ر...
15 صفحه اولX chromosome inactivation during induced differentiation of a female mouse embryonal carcinoma cell line.
P10 is a line of embryonal carcinoma cells with a euploid female karyotype. By making use of variant alleles of X-linked genes and of cytogenetic procedures, we have previously shown that the P10 cells have two genetically active X chromosomes. We show here that P10 cells rapidly differentiate into a cell type resembling extraembryonic endoderm when cultured in the presence of retinoic acid. Th...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2000
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80248-8